DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC 50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydr Appearance:Solid In Vitro:DPM-1001 trihydrochloride inhibits the short form of PTP1B reversibly, whereas PTP1B(1–405) remained inactive over an extended period of time. DPM-1001 is against PTP1B(1–405) with no pre-incubation, the IC 50 value for PTP1B(1–405) is 600 nM. However, af In Vivo:DPM-1001 trihydrochloride (oral or intraperitoneal administration; 5mg/kg; once daily; 50 days) inhibits diet-induced obesity in mice by improving insulin and leptin signaling. DPM-1001 trihydrochloride-treated, high-fat diet-fed mice starts losing weigh Biological Activity:DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC 50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydr
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DPM-1001 trihydrochloride
CAS number：unknown molecular formula：C35H60Cl3N3O3
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| Chinese alias | DPM-1001 三盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C35H60Cl3N3O3 |
| molecular weight | 677.23 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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