JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma. Appearance:Solid In Vitro:JQKD82 (0.3 μM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells. JQKD82 (0.1-10 μM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 trihydrochlorid In Vivo:JQKD82 (50-75mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity. JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo. MCE has n Biological Activity:JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma.
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JQKD82 trihydrochloride
CAS number：unknown molecular formula：C27H43Cl3N4O5
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| Chinese alias | JQKD82三盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C27H43Cl3N4O5 |
| molecular weight | 610.01 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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