RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells ( IC 50 of 3.0 μM). Appearance:Solid IC50& Target:IC50: 11.1 μM (RAD51-mediated D-loop formation) In Vitro:RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA). RI(dl)-2 does not modula Biological Activity:RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells ( IC 50 of 3.0 μM).
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RI(dl)-2 TFA
CAS number：unknown molecular formula：C19H17N3.(1.3)C2HF3O2
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| Chinese alias | RI(dl)-2三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C19H17N3.(1.3)C2HF3O2 |
| molecular weight | 435.59 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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