IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K i of 16 pM. IC50& Target:ET B In Vitro:IRL-1620 (TFA) is the most potent and specific ligand for the ETB receptor (K i ETA/ K i ETB=120,000) as judged by the K i values for ETA (19 μM) and ETB (16 PM) receptors. IRL-1620 (TFA) is 60 times more selective for the ETB receptor than ET-3 (K i In Vivo:IRL-1620 (TFA) (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL-1620 [1] . IRL-1620 (TFA) (1-100 nM) increases cytosolic Ca 2+ in th Biological Activity:IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K i of 16 pM.
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RdRP-IN-2
CAS number：unknown molecular formula：C88H118F3N17O29
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C88H118F3N17O29 |
| molecular weight | 1934.97 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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