compound introduction
ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC 50 value of 15 μM for TRPML1. Appearance:Solid IC50& Target:IC50: 15 μM (TRPML1) In Vitro:ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments co Biological Activity:ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC 50 value of 15 μM for TRPML1.
