CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CL pro (SC2) inhibitor with an IC 50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CL pro ) with an IC 50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COV IC50& Target:IC50: 68 nM (SC2) and 19 nM (SC1) In Vitro:CCF0058981 (CCF981) has cytopathic effect (CPE) inhibition (EC 50 =497 nM) and plaque reduction (EC 50 =558 nM) in vitro viral replication. CCF0058981 has the 50% cytotoxic concentration (CC 50 ) in the CPE antiviral assay of >50 μM. CCF0058981 Biological Activity:CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CL pro (SC2) inhibitor with an IC 50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CL pro ) with an IC 50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COV
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CCF0058981
CAS number：unknown molecular formula：C24H19ClN6O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C24H19ClN6O |
| molecular weight | 442.9 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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