Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect In Vitro Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl 2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl 2 . ? Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Gap junction.
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Danegaptide Hydrochloride
CAS number：943133-81-1 molecular formula：C14H18ClN3O4
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| Chinese alias | 盐酸达那普肽 | ||
| English alias | (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride | GAP-134 (Hydrochloride) | HY-10913A | MS-24899 | A916769 | DTXSID60659497 | GAP-134 (Hydrochloride);ZP 1609 Hydrochloride | Danegaptide Hydrochloride | danegaptide hcl | ZP | ||
| CAS number | 943133-81-1 | molecular formula | C14H18ClN3O4 |
| molecular weight | 327.76 g/mol | Exact mass | ≥99% |
| PSA | 113.000 Ų | logp | - |
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