compound introduction
RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity In Vitro RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC 50 =30 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulationMCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:α4β1 α4β7
