Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation In Vivo Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model. IC50& Target:IC50: 3.8 nM (Glucocorticoid receptor)
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Mizacorat
CAS number：1893415-00-3(DMSO) molecular formula：C27H28F2N4O3
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| Chinese alias | 米萨科拉特 | ||
| English alias | - | ||
| CAS number | 1893415-00-3(DMSO) | molecular formula | C27H28F2N4O3 |
| molecular weight | 494.53 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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