hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1 , with an IC 50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR ( IC 50 =50 nM), PI3Kα/γ ( IC 50 =92/60 nM) and CDK1/CDK2 ( IC 50 =32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer In Vitro hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells. hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC 50 of 75 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:hSMG-1 0.11 nM (IC 50 ) mTOR 50 nM (IC 50 ) PI3Kγ 60 nM (IC 50 ) PI3Kα 92 nM (IC 50 ) GSKα 260 (IC 50 ) GSKβ 330 (IC 50 ) CDK2 7.1 μM (IC 50 ) CDK1 32 μM (IC 50 )
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hSMG-1 inhibitor 11j
CAS number：1402452-15-6 molecular formula：C27H28ClN7O3S
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| Chinese alias | hSMG-1 抑制剂 11j | ||
| English alias | - | ||
| CAS number | 1402452-15-6 | molecular formula | C27H28ClN7O3S |
| molecular weight | 566.07 g/mol | Exact mass | ≥99% |
| PSA | 138.000 Ų | logp | 3.800 |
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