Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK In Vitro Cearoin (10-80 μM) induces cell death in a dose-dependent manner. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot AnalysisCell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner. Form:Solid IC50& Target:ERK ROS Autophagy Apoptosis
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Cearoin
CAS number：52811-37-7 molecular formula：C14H12O4
overview
compound introduction
Specs
| Chinese alias | 麦角酸 | ||
| English alias | SDCCGMLS-0066944.P001 | Spectrum5_000314 | KBio2_006208 | KBioSS_001072 | (2,5-dihydroxy-4-methoxyphenyl)(phenyl)methanone | DivK1c_006214 | AKOS040761474 | NCGC00095562-02 | KBio3_002189 | BRD-K20420220-001-03-9 | HY-N8418 | Spectrum_000592 | SpecPlus_00 | ||
| CAS number | 52811-37-7 | molecular formula | C14H12O4 |
| molecular weight | 244.24 g/mol | Exact mass | ≥98% |
| PSA | 66.800 Ų | logp | 3.100 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
