VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer. In Vitro VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NCI-H226-tumor bearing mice Dosage: 0.3, 1, and 3 mg/kg Administration: Oral administration Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner. Form:Solid
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VT104
CAS number：2417718-25-1 molecular formula：C25H19F3N2O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2417718-25-1 | molecular formula | C25H19F3N2O |
| molecular weight | 420.43 g/mol | Exact mass | - |
| PSA | - | logp | - |
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