BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC 50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer In Vitro BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC 50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC 50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased K m and decreased V max. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 37 μM (ITPKA),20 μM (InsP3 kinase)
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BAMB-4
CAS number：891025-25-5(DMSO) molecular formula：C15H12N2O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 891025-25-5(DMSO) | molecular formula | C15H12N2O2 |
| molecular weight | 252.27 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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