compound introduction
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC 50 s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA , TrkB and TrkC , respectively Anti-hyperalgesic effect In Vitro PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC 50 >5 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:TrkA 1.9 nM (IC 50 , in cell-based assays) TrkB 2.6 nM (IC 50 , in cell-based assays) TrkC 1.1 nM (IC 50 , in cell-based assays)
