Brofaromine (CGP 11305A) is a monoamine oxidase ( MAO ) inhibitor with IC 50 of 0.2 μM for MAO-A . In Vitro In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.2 μM (MAO-A)
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Brofaromine
CAS number：63638-91-5(DMSO) molecular formula：C14H16BrNO2
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| Chinese alias | 溴法罗明 | ||
| English alias | - | ||
| CAS number | 63638-91-5(DMSO) | molecular formula | C14H16BrNO2 |
| molecular weight | 310.19 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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