compound introduction
(R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 ( WT IDH1 ) inhibitor with an IC 50 value of 120 nM. (R,R)-GSK321 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity In Vitro (R,R)-GSK321 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IDH1
