Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC 50 s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs In Vitro Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines Concentration: 0-1 μM Incubation Time: 72 hours Result: Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC 50 values of 5, 19, 2, 0.4 and 1 nM, respectively. Form:Solid IC50& Target:IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)
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Nampt-IN-10 TFA
CAS number：2567724-20-1 molecular formula：C27H28FN5O2..xC2HF3O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2567724-20-1 | molecular formula | C27H28FN5O2..xC2HF3O2 |
| molecular weight | - | Exact mass | - |
| PSA | - | logp | - |
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