Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor ( IC 50 =13 nM). In Vitro In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir fumarate shows the EC 50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants. EC 50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Ensitrelvir fumarate dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Ensitrelvir fumarate
CAS number：2757470-18-9 molecular formula：C26H21ClF3N9O6
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| Chinese alias | 富马酸恩西特韦 | ||
| English alias | - | ||
| CAS number | 2757470-18-9 | molecular formula | C26H21ClF3N9O6 |
| molecular weight | 647.95 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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