Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC 50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373. In Vitro Glucocorticoid receptor agonist-2 shows glucocorticoid receptor (GR) and progersterone receptor (PR) binding activities with IC 50 values of 6.6 and 7.3 nM, respectively. Glucocorticoid receptor agonist-2 shows EC 50 values of 0.2 and 442 nM to glucocorticoid responsive element (GRE) reporter and mineralcorticoid receptor (MR), respectively. Glucocorticoid receptor agonist-2 agonists MR with an EC 50 value of 149 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Glucocorticoid receptor agonist-2
CAS number：2166378-92-1 molecular formula：C34H35F2NO7
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| Chinese alias | 糖皮质激素受体激动剂-2 | ||
| English alias | - | ||
| CAS number | 2166378-92-1 | molecular formula | C34H35F2NO7 |
| molecular weight | 607.64 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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