Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects. In Vitro Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Isolated rabbit aortic strip Concentration: 0.1-10 μM Incubation Time: 20 min Result: Showed pA 2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively. In Vivo Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male spontaneously hypertensive rats (SHR) Dosage: 12.5, 25, or 50 mg/kg Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days Result: Produced a dose-related fall in blood pressure. Form:Solid
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Medroxalol
CAS number：56290-94-9 molecular formula：C20H24N2O5
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| Chinese alias | 美沙洛尔 | ||
| English alias | RMI 81968;RMI-81968;RMI81968 | 5-(1-Hydroxy-2-((1-methyl-3-(3,4-(methylenedioxy)phenyl)propyl)amino)ethyl)salicylamide | Medroxalol (USAN/INN) | EINECS 260-099-3 | Medroxalol [USAN:INN:BAN] | DTXSID30866550 | (1R,2R)-FMOC-2-AMINOCYCLOPENTANECARBOXYLICACID | ||
| CAS number | 56290-94-9 | molecular formula | C20H24N2O5 |
| molecular weight | 372.41 g/mol | Exact mass | ≥99% |
| PSA | 114.000 Ų | logp | 2.900 |
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