Valecobulin (CKD516) is a valine proagent of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors In Vivo Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells Dosage: 5 mg/kg Administration: Intraperitoneal injection; administered on days 2, 6, 10, and 14 Result: Had shown marked antitumor efficacy in various human tumor xenograft models. IC50& Target:β-tubulin polymerization
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Valecobulin
CAS number：1188371-47-2(DMSO) molecular formula：C26H28N6O5S
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| Chinese alias | 伐可布林 | ||
| English alias | - | ||
| CAS number | 1188371-47-2(DMSO) | molecular formula | C26H28N6O5S |
| molecular weight | 536.60 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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