ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. In Vitro ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro . ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI 50 =6.7-11.2 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Cdk4/cyclin D1
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ON-013100
CAS number：865783-95-5(DMSO) molecular formula：C19H22O7S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 865783-95-5(DMSO) | molecular formula | C19H22O7S |
| molecular weight | 394.44 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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