Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
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Recombinant Human LAIR1 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 白细胞关联免疫球蛋白样受体1(LAIR1)重组蛋白 | ||
| English alias | CD305 | CD305 antigen | CD305leukocyte-associated Ig-like receptor 1 | HLAIR1 | LAIR1 | LAIR-1 | leukocyte-associated immunoglobulin-like receptor 1 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
numbering system
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physicochemical properties
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MSDS
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