Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
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Recombinant Human Convertase 9/PCSK9 Protein
CAS number：unknown molecular formula：
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| Chinese alias | 重组人Convertase 9/PCSK9蛋白 | 重组人前蛋白转化酶枯草溶菌素9 | 重组人类转化酶 9/PCSK9 蛋白 | ||
| English alias | EC 3.4.21.111 | EC 3.4.21 | FH3 | FH3neural apoptosis regulated convertase 1 | FHCL3 | HCHOLA3 | hypercholesterolemia, autosomal dominant 3 | LDLCQ1 | NARC1 | NARC-1 | NARC-1convertase subtilisin/kexin type 9 preproprotein | NARC1EC 3.4.21.- | Neural apop | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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