Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
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Recombinant Human CDK4 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人CDK4蛋白 | 重组人类 CDK4 蛋白 | ||
| English alias | cdk4 | CDK4 protein | CDK4_HUMAN | Cell division kinase 4 | Cell division protein kinase 4 | CMM 3 | CMM3 | Crk3 | Cyclin dependent kinase 4 | Cyclin-dependent kinase 4 | Melanoma cutaneous malignant 3 | MGC14458 | p34 cdk4 | Cdk 4 | PSK J3 | PSK-J3 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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