Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： p21CIP1, also called CIP1 (CDK-interacting protein 1) and CDKN1A, is a 21 kDa Cyclin/Cyclin-dependent kinase (Cdk) inhibitor that blocks cell cycle progression from G1 to S phase in the cell cycle. Because p21 is a transcriptional target of the p53 tumor suppressor, p21 expression increases in cells that contain stabilized p53 due to genotoxic stress exposure. May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Recombinant Human p21 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人p21蛋白 | 重组人类 p21 蛋白 | ||
| English alias | CAP20 | CDK-interacting protein 1 | CDKI | CDKN1 | Cdkn1a | CDN1A_HUMAN | CIP1 | Cyclin Dependent Kinase Inhibitor 1A | Cyclin-dependent kinase inhibitor 1 | Cyclin-dependent kinase inhibitor 1A (P21) | DNA Synthesis Inhibitor | Cyclin-dependent kinase in | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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