compound introduction
TL12-186 是一种依赖于 Cereblon 的多激酶 PROTAC 降解剂。包括 CDK，BTK，FLT3，Aurora激酶，TEC，ULK，ITK 等。TL12-186 抑制 CDK2/cyclin A 和 CDK9/cyclin T1，IC50 分别为 73 和 55 nM。
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TL 12-186
CAS number：2250025-88-6 molecular formula：C44H51ClN10O9S
overview
Specs
| Chinese alias | N-(2-(2-(2-(4-(4-((5-5-氯-4-((2-(异丙基磺酰基)苯基)氨基)嘧啶-2-基)氨基)苯基)哌嗪-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide | ||
| English alias | N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide | ||
| CAS number | 2250025-88-6 | molecular formula | C44H51ClN10O9S |
| molecular weight | 931.46 g/mol | Exact mass | - |
| PSA | 242.000 Ų | logp | 4.600 |
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