PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC 50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner In Vitro PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%. PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 1-10 μM Incubation Time: 24 hours Result: Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively. Form:Solid IC50& Target:Cereblon
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PROTAC PD-1/PD-L1 degrader-1
CAS number：2447066-37-5 molecular formula：C59H58ClN7O11
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| Chinese alias | PROTAC PD-1/PD-L1 降解剂-1 | ||
| English alias | - | ||
| CAS number | 2447066-37-5 | molecular formula | C59H58ClN7O11 |
| molecular weight | 1076.59 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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