CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a K d of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC 50 of 7.3 μM In Vitro CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8. CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM. CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Human CCR7 3 nM (Kd)
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CCR7 Ligand 1
CAS number：681514-83-0 molecular formula：C22H29N5O5S
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| Chinese alias | CCR7 配体 1 | ||
| English alias | - | ||
| CAS number | 681514-83-0 | molecular formula | C22H29N5O5S |
| molecular weight | 475.56 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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