多韦替尼二乳酸是一种有效的、非特异性的生长因子受体激酶抑制剂，对Flt-3、c-kit、VEGFR、PDGFR和CSF-1R均有抑制作用。 产品应用： Dovitinib Dilactic Acid 是 Dovitinib 的双乳酸，是一种多靶点 RTK 抑制剂，主要用于 III 类 (FLT3/c-Kit)，IC50 为 1 nM/2 nM，对 IV 类 (FGFR1/ 3) 和 V 类 (VEGFR1-4) RTK，IC50 为 8-13 nM，对 InsR、EGFR、c-Met、EphA2、Tie2、IGFR1 和 HER2 的效力较低。 Product Describtion: Dovitinib Dilactic acid is a potent, non-specific growth factor receptor kinase inhibitor with effects against FLT-3, c-KIT, VEGFR, PDGFRß and CSF-1R, respectively. Product Application: Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2.
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Dovitinib (TKI-258) Dilactic Acid
CAS number：852433-84-2 molecular formula：C21H21FN6O·2C3H6O3
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compound introduction
Specs
| Chinese alias | 多韦替尼(TKI-258)双乳酸 | ||
| English alias | CHIR-258 Dilactic acid | Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone | ||
| CAS number | 852433-84-2 | molecular formula | C21H21FN6O·2C3H6O3 |
| molecular weight | 572.59 g/mol | Exact mass | 10mM in DMSO |
| PSA | 205.000 Ų | logp | - |
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