Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines. In Vitro Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC 50 of 1-5 μM. Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity. Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human myeloid THP-1, HL-60, U-118 MG, U-87 MG and U-937 cells Concentration: 1-50 μM Incubation Time: 24 hours Result: Reduced viability of five different cell lines in a concentration-dependent manner. In Vivo Asukamycin (0-450 mg/kg; i.p.; mice) has low toxicity in vivo. Asukamycin has acute toxicity with an LD 50 value of 48.5 mg/kg by intraperitoneal injection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MiceDosage: 0-450 mg/kg Administration: Intraperitoneal injection Result: Had no effect on mice when administered by 450 mg/kg and the acute toxicity (LD 50 ) was 48.5 mg/kg by intraperitoneal injection. Form:Solid
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Asukamycin
CAS number：61116-33-4 molecular formula：C31H34N2O7
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| Chinese alias | 飞鸟霉素 | ||
| English alias | BRN 3639742 | asukamycin A1 | CHEBI:73481 | (2E,4E,6E)-7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]hepta-2,4,6-trienamide | AM 1042 | | ||
| CAS number | 61116-33-4 | molecular formula | C31H34N2O7 |
| molecular weight | 546.61 g/mol | Exact mass | ≥95% |
| PSA | 145.000 Ų | logp | 3.500 |
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