compound introduction
ML 2-14 is a PROTAC for degrading BRD4 , with C4 alkyl linker. ML 2-14 exerts degradation of BRD4 in 231MFP breast cancer cells. Appearance:Solid In Vitro:ML 2-14 with C4 alkyl linker showes robust degradation of BRD4 in 231MFP breast cancer cells, with DC 50 values of 36 and 14 nM for the long and short isoforms of BRD4, respectively. MCE has not independently confirmed the accuracy of these methods. Biological Activity:ML 2-14 is a PROTAC for degrading BRD4 , with C4 alkyl linker. ML 2-14 exerts degradation of BRD4 in 231MFP breast cancer cells.
