SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. Appearance:Solid IC50& Target:Cereblon In Vitro:SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:SJF620 hydrochloride has a super pharmacokinetic profile in mice (1mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802. MCE has not independently confirmed the accuracy of the Biological Activity:SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.
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SJF620 hydrochloride
CAS number：unknown molecular formula：C41H45ClN8O7
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compound introduction
Specs
| Chinese alias | SJF620盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C41H45ClN8O7 |
| molecular weight | 797.3 g/mol | Exact mass | - |
| PSA | - | logp | - |
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