compound introduction
Danoprevir (ITMN-191, RG7227) 是一种肽类抑制剂，作用于丙型肝炎病毒(HCV)的NS3/4A蛋白酶，IC50为0.2-3.5 nM，抑制HCV 1A/1B/4/5/6基因型比抑制2B/3A基因型效果高10倍左右。
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Danoprevir
CAS number：850876-88-9 molecular formula：C35H46FN5O9S
overview
Specs
| Chinese alias | - | ||
| English alias | Ganovo | R7227 | UNII-911Z9PCQ5F | CCG-270417 | Danoprevir (ITMN-191) | (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | BIDD:GT0614 | DANOPREVIR [INN] | ITMN B | 4-Fluoro-1,3-dihydro-2h-isoindole-2-carboxyl | ||
| CAS number | 850876-88-9 | molecular formula | C35H46FN5O9S |
| molecular weight | 731.85 g/mol | Exact mass | ≥95% |
| PSA | 189.000 Ų | logp | 3.3 |
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