CAS number：2080306-20-1 molecular formula：C28H34N4O2
TP-064 是一种有效的选择性蛋白精氨酸甲基转移酶 4 (PRMT4; CARM1) 抑制剂 (IC50 Application: TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.
| Chinese alias | N-甲基-N-(((2-(1-(2-(甲基氨基)乙基)哌啶-4-基)吡啶-4-基)甲基)-3-苯氧基苯甲酰胺 | ||
| English alias | N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide | ||
| CAS number | 2080306-20-1 | molecular formula | C28H34N4O2 |
| molecular weight | 458.6 g/mol | Exact mass | - |
| PSA | 57.700 Ų | logp | 3.500 |
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