compound introduction
TL4-12 是一种选择性 MAP4K2/GCK 抑制剂，下调 IKZF1 和 BCL-6，并抑制 MM 细胞增殖 (IC50=37 nM) 并诱导细胞凋亡。TL4-12 可用于克服多发性骨髓瘤 (MM) 中免疫调节剂的耐药性。
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TL4-12
CAS number：1620820-12-3 molecular formula：C25H27F3N6O2
overview
Specs
| Chinese alias | 4-甲基-3-[[[6-(甲基氨基)-4-嘧啶基]氧基] -N-[3-(4-甲基-1-哌嗪基)-5-(三氟甲基)苯基]苯甲酰胺 | ||
| English alias | 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide | ||
| CAS number | 1620820-12-3 | molecular formula | C25H27F3N6O2 |
| molecular weight | 500.53 g/mol | Exact mass | ≥96%(HPLC) |
| PSA | - | logp | - |
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