AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC 50 s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. In Vitro AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TrkA 2 nM (IC 50 ) TrkB 8 nM (IC 50 )
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AZ-23
CAS number：915720-21-7 molecular formula：C17H19ClFN7O
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| Chinese alias | - | ||
| English alias | 5-Chloro-N2-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | 5-Chloro-N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | AZ23 | AZ-23 | UNII-009OMI967N | (S)-5-Chl | ||
| CAS number | 915720-21-7 | molecular formula | C17H19ClFN7O |
| molecular weight | 391.83 g/mol | Exact mass | ≥98% |
| PSA | 101.000 Ų | logp | 3.700 |
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