compound introduction
Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).(1) The reference for administration is 0.25-0.75 mg/kg IP (2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake.(3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons.(4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.
