Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain. In Vivo Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Sprague-Dawley CD rats (200-250 g)Dosage: 200 mg/kg Administration: i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result: Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. Form:Solid
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Pivagabine
CAS number：69542-93-4 molecular formula：C9H17NO3
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| Chinese alias | 匹伐加宾 | ||
| English alias | Pivagabine | CHEBI:134834 | 4-(2 pound not2-dimethylpropanoylamino)butanoic acid | 4-Pivalamidobutanoicacid | 4-Pivalamidobutyric acid | 4-Pivalamido-butyric acid | DB12951 | EN300-27463 | AKOS000127419 | DTXSID3046162 | Pivagabine (INN) | Butyric acid, 4 | ||
| CAS number | 69542-93-4 | molecular formula | C9H17NO3 |
| molecular weight | 187.239 g/mol | Exact mass | ≥99% |
| PSA | 66.400 Ų | logp | 0.800 |
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