JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively. In Vitro JNJ-42041935 is the most potent inhibitor of PHD2 181–417 with a pIC 50 value of 7.0±0.03. JNJ-42041935 also inhibits full-length PHD1, PHD2, and PHD3 enzymes (pK i values 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo JNJ-42041935 is used to compare the effect of selective inhibition of PHD to intermittent, high doses (50 μg/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation induced anemia model in rats. JNJ-42041935 (100 μmol/kg, once a day for 14 days) is effective in reversing inflammation induced anemia, whereas erythropoietin has no effect. Administration of JNJ-42041935 (100 μmol/kg p.o.) for 5 consecutive days resulted in a 2-fold increase in reticulocytes, an increase in hemoglobin by 2.3 g/dl, and an increase in the hematocrit of 9%. Two hours after oral administration of 300 μmol/kg JNJ-42041935, the bioluminescence over the peritoneal area is increased by 2.2 ± 0.3-fold relative to luciferase-treated vehicle controls in the mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:pK i : 7.91±0.04 (PHD1), 7.29 ±0.05 (PHD2), 7.65±0.09(PHD3)
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JNJ-42041935
CAS number：1193383-09-3 molecular formula：C12H6ClF3N4O3
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| Chinese alias | - | ||
| English alias | AZACITIDINE (USP-RS) | 1-[6-chloro-5-(trifluoromethoxy)-1H-1,3-benzodiazol-2-yl]-1H-pyrazole-4-carboxylic acid | 1H-Pyrazole-4-carboxylic acid, 1-(6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl)- | Q27289665 | BDBM50446900 | BS-14602 | JNJ42041935 | J | ||
| CAS number | 1193383-09-3 | molecular formula | C12H6ClF3N4O3 |
| molecular weight | 346.65 g/mol | Exact mass | ≥99% |
| PSA | 93.000 Ų | logp | 3.100 |
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