Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity ( IC 50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent In Vivo Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g Dosage: 0.3, 1, 3, 30 mg/kg Administration: Subcutanous injections Result: Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. Form:Solid IC50& Target:IC50: 6 nM (sigma receptor)
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Panamesine
CAS number：139225-22-2 molecular formula：C23H26N2O6
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| Chinese alias | - | ||
| English alias | 2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)- | Panamesine | Panamesine [INN] | Q27231486 | (5S)-5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxypiperidin-1-yl]methyl]-3-(4-methoxyphenyl)-1,3-oxazolidin-2- | ||
| CAS number | 139225-22-2 | molecular formula | C23H26N2O6 |
| molecular weight | 426.46 g/mol | Exact mass | ≥99% |
| PSA | 80.700 Ų | logp | 2.500 |
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