IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1 , with an IC 50 of 8 nM for TRIM24, and K d s of 31 nM and 14 nM for TRIM24 and BRPF1 , respectively In Vitro IACS-9571 Hydrochloride shows excellent cellular potency with EC 50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (K d =1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 8 nM (TRIM24), Kd: 31 nM (TRIM24), 14 nM (BRPF1)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
IACS-9571 hydrochloride
CAS number：2319611-93-1 molecular formula：C32H43ClN4O8S
overview
compound introduction
Specs
| Chinese alias | IACS-9571 盐酸盐 | ||
| English alias | - | ||
| CAS number | 2319611-93-1 | molecular formula | C32H43ClN4O8S |
| molecular weight | 679.22 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
