compound introduction
ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways In Vitro ML148 (compound 13) shows selectivity with IC 50 s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively. ML148 (10, 20 nM) decrease V max by 25% and reduces the apparent K m by half at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 56 nM (15-PGDH)
