CAS number：942206-85-1 molecular formula：C28H32Cl2N4O6S2
一般描述： GSK1016790A 是有效的，选择性瞬时受体电位香草酸 4 (TRPV4) 通道激活剂。GSK1016790A 可以引起 HEK 细胞中 Ca2+ 流入并升高细胞内 Ca2+。 用途： GSK1016790A可用于：刺激非洲爪蟾卵母细胞中瞬时受体电位香草素亚型4 (TRPV4)介导的电流；刺激人视网膜毛细血管内皮细胞(HRCEC)中钙2+ 水平的测定；研究TRPV4通道在脑出血(ICH)后脑损伤中的作用；触发牛髓核细胞或Hanks′平衡盐溶液中TRPV4通道 GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells。
| Chinese alias | (N-((1S)-1-{[4-((2S)-2-{[(2,4-二氯苯基)磺酰基]氨基}-3-羟基丙酰基)-1-哌嗪基]羰基}-3-甲基丁基)-1-苯并噻吩-2-甲酰胺 | ||
| English alias | GSK101 | HY-19608 | GSK 1016790A | N-[(2S)-1-[4-[(2S)-2-[(2,4-dichlorophenyl)sulfonylamino]-3-hydroxypropanoyl]piperazin-1-yl]-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide | AC-33152 | GTPL4205 | IVYQPSHHYIAUFO-VXKWHMMOSA-N | N-[(2S)-1-{4-[N- | ||
| CAS number | 942206-85-1 | molecular formula | C28H32Cl2N4O6S2 |
| molecular weight | 655.61 g/mol | Exact mass | - |
| PSA | 173.000 Ų | logp | 4.400 |
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