CDDO-EA is an NF-E2 related factor 2/antioxidant response element ( Nrf2/ARE ) activator. In Vitro CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p Form:Solid IC50& Target:Nrf2/ARE
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
CDDO-EA
CAS number：932730-51-3 molecular formula：C33H46N2O3
overview
compound introduction
Specs
| Chinese alias | 丙二醇 | ||
| English alias | - | ||
| CAS number | 932730-51-3 | molecular formula | C33H46N2O3 |
| molecular weight | 518.73 g/mol | Exact mass | ≥99% |
| PSA | 87.000 Ų | logp | 6.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
