CAS number：913376-83-7 molecular formula：C30H29N5O5
AMG-458 是有效的、选择性的 的 c-Met 抑制剂，其对人和小鼠的 Ki 值分别为 1.2 nM 和 2.0 nM。 Product Describtion: AMG-458 is a potent, selective and orally bioavailable c-Met inhibitor, with Ki values of 1.2 nM and 2.0 nM for human and mouse c-Met, respectively.
| Chinese alias | - | ||
| English alias | 2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-Pyrazole-4-carboxamide;AMG-458 | 2-(4-hydroxy-3-methoxyphenyl)-ethylamine | 4535RW5Y3A | AMG 458 | Substituted Pyrazolone, 17 | NSC754346 | | ||
| CAS number | 913376-83-7 | molecular formula | C30H29N5O5 |
| molecular weight | 539.58 g/mol | Exact mass | ≥99% |
| PSA | 117.000 Ų | logp | 4.000 |
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