CAS number：228559-41-9 molecular formula：C24H18F3N3O4
Ki8751是高活性VEGFR2选择性抑制剂，IC50为0.9 nM，比对c-Kit，PDGFRα和FGFR-2的抑制性高40倍，对EGFR，HGFR和 InsR几乎无活性。A cell-permeable Flk-1 (VEGFR-2) and c-Kit inhibitor Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR. A cell-permeable Flk-1 (VEGFR-2) and c-Kit inhibitor
| Chinese alias | - | ||
| English alias | 1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea | HMS1787L13 | SB19355 | BRD-K47150025-001-01-2 | 1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea | 1-(2,4-Difluorophenyl)-3-(4-(6,7-dime | ||
| CAS number | 228559-41-9 | molecular formula | C24H18F3N3O4 |
| molecular weight | 469.41 g/mol | Exact mass | ≥98% |
| PSA | 81.700 Ų | logp | 4.500 |
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