CAS number：1035638-91-5 molecular formula：C18H14ClFN4O2
PF 6274484 is a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM. PF 6274484 inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
| Chinese alias | N-[4-[(3-氯-4-氟苯基)氨基] -7-甲氧基-6-喹唑啉基] -2-丙烯酰胺 | ||
| English alias | PF-6274484 | N-4-(3-Chloro-4-fluorophenyl)amino-7-methoxy-6-quinazolinyl-2-propenamide | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide | ||
| CAS number | 1035638-91-5 | molecular formula | C18H14ClFN4O2 |
| molecular weight | 372.78 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 76.100 Ų | logp | 3.900 |
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