Product description： A cell-permeable, reversible, ATP-competitive, and tricyclic, benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 300 nM for c-fms, c-kit, wt-FLT3, and internal tandem duplication (ITD)-FLT3; 1 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, Akt, PKC, MEK, or ERK1/2 (IC50 >10 µM). Inhibits FLT-3 ligand-dependent growth of Ba/F3 cells expressing wild type FLT-3. Reported to be useful in differentiating signal transduction pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells. A cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, AKT, PKC, MEK, or ERK1/2 (IC50 ≥ 10 µM). Has been used successfully to differentiate between the signalling pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
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GTP 14564
CAS number：34823-86-4 molecular formula：C15H10N2O
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| Chinese alias | - | ||
| English alias | HSCI1_000176 | BRD-K16664969-001-01-7 | GTPL5982 | CCG-206757 | GTP 14564 | AKOS024456938 | HMS3413E13 | J-019773 | Q27077928 | 3-phenyl-2h-benzofuro[3,2-c]pyrazole | 1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden | SCHEMBL2550165 | 3-phenyl-1H-[1]benzof | ||
| CAS number | 34823-86-4 | molecular formula | C15H10N2O |
| molecular weight | 234.26 g/mol | Exact mass | - |
| PSA | 41.800 Ų | logp | 3.700 |
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