compound introduction
Information Baricitinib phosphate (INCB-028050, LY-3009104) is a selectiveJAK1andJAK2inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Targets JAK2 (Cell-free assay); JAK1 (Cell-free assay); TYK2 (Cell-free assay); JAK3 (Cell-free assay) 5.7 nM; 5.9 nM; 53 nM; >400 nM
